About   Help   FAQ
Adamts4tm1Dgen
Targeted Allele Detail
Nomenclature
Symbol: Adamts4tm1Dgen
Name: a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 4; targeted mutation 1, Deltagen
MGI ID: MGI:3604481
Gene: Adamts4  Location: Chr1:171250421-171260637 bp, + strand  Genetic Position: Chr1, 79.28 cM
Mutation
origin
Mutant Cell Line:  3733
Germline Transmission:  Earliest citation of germline transmission: J:101679
Parent Cell Line:  E14 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Project Collection: Deltagen
Mutation
description
Allele Type:    Targeted (Null/knockout, Reporter)
Mutation:    Insertion
 
Mutation detailsA bacterial lacZ gene was inserted into the gene such that the endogenous gene promoter drives expression of beta-galactosidase. The highest levels of RNA transcripts are detectable in whole brain, cortex, subcortical region, cerebellum, brainstem, olfactory bulb, spinal cord, ovary and uterus. Moderate levels of RNA transcripts are detectable in eye, Harderian glands, lung, pancreas, kidney, spleen, thymus, lymph nodes, bone marrow, skin, gallbladder, urinary bladder, pituitary gland, adrenal gland, salivary gland, skeletal muscle, tongue, stomach, small intestine, cecum, colon, testis, epididymis, seminal vesicle, coagulating gland, prostate gland, and white fat. Lower levels of RNA transcripts are also detectable in heart. LacZ (beta-galactosidase) expression is detectable in brain, spinal cord, eyes, bone marrow, tongue, skin, ear, male and female reproductive systems.
Phenotypes
Loading...
View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 75 assay results
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Adamts4 Mutation:  25 strains or lines available
Notes
See also, data as provided by Deltagen, Inc.
References
Original:  J:101679 Deltagen Inc, NIH initiative supporting placement of Deltagen, Inc. mice into public repositories. MGI Direct Data Submission. 2005;
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
09/12/2017
MGI 6.10
The Jackson Laboratory