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Inpp5aGt(OST50073)Lex
Gene trapped Allele Detail
Nomenclature
Symbol: Inpp5aGt(OST50073)Lex
Name: inositol polyphosphate-5-phosphatase A; gene trap OST50073, Lexicon Genetics
MGI ID: MGI:3604476
Synonyms: Inpp5aGt694Lex
Gene: Inpp5a  Location: Chr7:139389109-139579652 bp, + strand  Genetic Position: Chr7, 84.57 cM
Mutation
origin
Mutant Cell Line:  OST50073
Germline Transmission:  Earliest citation of germline transmission: J:103485
Parent Cell Line:  Lex-1 (ES Cell)
Strain of Origin:  129S5/SvEvBrd
Project Collection: Lexicon
Mutation
description
Allele Type:    Gene trapped (Hypomorph)
Mutation:    Insertion of gene trap vector
 
Mutation detailsRetroviral gene trap insertion occurred between exons 8 and 9. The insertion truncated the protein after amino acid 215, removing half of the protein including the predicted active site. RT-PCR analysis of P0 mutants confirmed elimination of wild-type mRNA. No truncated protein was detected by Western blot analysis; however, a small amount of normal protein was detected in both homozygous and heterozygous mutants, probably due to a small amount of splicing around the gene trap. (J:103485, J:249381)
Sequence Tags: 
Sequence tag details (1 tag)
Genome Context: 
Genome Browser view of this mutation
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 2 strains available      Cell Lines: 1 line available
Carrying any Inpp5a Mutation:  18 strains or lines available
Notes
See also, data as provided by Lexicon Genetics, Inc.
References
Original:  J:103485 Lexicon Genetics Inc, NIH initiative supporting placement of Lexicon Genetics, Inc. mice into public repositories. MGI Direct Data Submission. 2005;
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
04/17/2018
MGI 6.11
The Jackson Laboratory