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Targeted Allele Detail
Symbol: Htr5atm1Dgen
Name: 5-hydroxytryptamine (serotonin) receptor 5A; targeted mutation 1, Deltagen
MGI ID: MGI:3604475
Gene: Htr5a  Location: Chr5:28047147-28060086 bp, + strand  Genetic Position: Chr5, 13.24 cM, cytoband A3-B
Alliance: Htr5atm1Dgen page
Mutant Cell Line:  893
Germline Transmission:  Earliest citation of germline transmission: J:101679
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Project Collection: Deltagen
Allele Type:    Targeted (Null/knockout, Reporter)
Mutation:    Disruption caused by insertion of vector
Mutation detailsA bacterial lacZ gene was inserted into the gene such that the endogenous gene promoter drives expression of beta-galactosidase. Low levels of RNA transcripts are detectable in brain, cortex, subcortical region, cerebellum, brainstem, olfactory bulb, spinal cord, eye, skin, pituitary gland, adrenal gland, ovary, and white fat but not in Harderian glands, heart, lung, liver, pancreas, kidney, spleen, thymus, lymph nodes, bone marrow, gallbladder, urinary bladder, salivary gland, skeletal muscle, tongue, stomach, small intestine, large intestine, cecum, testis, epididymis, seminal vesicle, coagulating gland, prostate gland and uterus. LacZ (beta-galactosidase) expression is detectable in brain and esophagus. In brain, staining is restricted to the cerebellum with Purkinje cells and nuclei in the granular layer displaying expression.
View phenotypes and curated references for all genotypes (concatenated display).
In Mice Carrying this Mutation: 66 assay results
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Htr5a Mutation:  12 strains or lines available
See also, data as provided by Deltagen, Inc.
Original:  J:101679 Deltagen Inc, NIH initiative supporting placement of Deltagen, Inc. mice into public repositories. MGI Direct Data Submission. 2005;
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
MGI 6.22
The Jackson Laboratory