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Liastm1Mae
Targeted Allele Detail
Nomenclature
Symbol: Liastm1Mae
Name: lipoic acid synthetase; targeted mutation 1, Nobuyo Maeda
MGI ID: MGI:3604218
Synonyms: Lias-
Gene: Lias  Location: Chr5:65548840-65567766 bp, + strand  Genetic Position: Chr5, 33.66 cM, cytoband C3.3
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:101368
Parent Cell Line:  W4 (ES Cell)
Strain of Origin:  129S6/SvEvTac
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA 3.7 kb sequence including exons 4-6 was replaced by a neomycin resistance gene. The deleted sequence encoded the functionally conserved Cys motifs, and loss of it resulted in a null allele. (J:101368)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 1 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Lias Mutation:  21 strains or lines available
References
Original:  J:101368 Yi X, et al., Endogenous production of lipoic acid is essential for mouse development. Mol Cell Biol. 2005 Sep;25(18):8387-92
All:  4 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
11/30/2021
MGI 6.17
The Jackson Laboratory