Lias^tm1Mae
Targeted Allele Detail

Summary

• Symbol: Lias^tm1Mae
• Name: lipoic acid synthetase; targeted mutation 1, Nobuyo Maeda
• MGI ID: MGI:3604218
• Synonyms: Lias^-
• Gene: Lias Location: Chr5:65548840-65567766 bp, + strand Genetic Position: Chr5, 33.66 cM, cytoband C3.3
• Alliance: Lias^tm1Mae page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:101368
• Parent Cell Line: W4 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A 3.7 kb sequence including exons 4-6 was replaced by a neomycin resistance gene. The deleted sequence encoded the functionally conserved Cys motifs, and loss of it resulted in a null allele. (J:101368)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Lias Mutation: 25 strains or lines available

References

• Original: J:101368 Yi X, et al., Endogenous production of lipoic acid is essential for mouse development. Mol Cell Biol. 2005 Sep;25(18):8387-92
• All: 4 reference(s)