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Targeted Allele Detail
Symbol: Rassf1tm1.2Brd
Name: Ras association (RalGDS/AF-6) domain family member 1; targeted mutation 1.2, Allan Bradley
MGI ID: MGI:3604205
Synonyms: Rossf1ABrdm2
Gene: Rassf1  Location: Chr9:107551555-107562267 bp, + strand  Genetic Position: Chr9, 58.12 cM
Germline Transmission:  Earliest citation of germline transmission: J:101369
Parent Cell Line:  AB2.2 (ES Cell)
Strain of Origin:  129S7/SvEvBrd-Hprtb-m2
Allele Type:    Targeted (Null/knockout)
Mutation:    Insertion
Mutation detailsTransfecting ES cells containing a floxed 1alpha exon with mice expressing cre recombinase resulted in the excision of the exon, thereby ablating isoform 1A expression. RT-PCR of lung confirmed absence of transcript from the exon, while the 1C isoform remained unaffected. (J:101369)
View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Rassf1 Mutation:  12 strains or lines available
Original:  J:101369 van der Weyden L, et al., The RASSF1A isoform of RASSF1 promotes microtubule stability and suppresses tumorigenesis. Mol Cell Biol. 2005 Sep;25(18):8356-67
All:  6 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 6.08
The Jackson Laboratory