About   Help   FAQ
Rassf1tm1.2Brd
Targeted Allele Detail
Nomenclature
Symbol: Rassf1tm1.2Brd
Name: Ras association (RalGDS/AF-6) domain family member 1; targeted mutation 1.2, Allan Bradley
MGI ID: MGI:3604205
Synonyms: Rossf1ABrdm2
Gene: Rassf1  Location: Chr9:107551555-107562267 bp, + strand  Genetic Position: Chr9, 58.12 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:101369
Parent Cell Line:  AB2.2 (ES Cell)
Strain of Origin:  129S7/SvEvBrd-Hprtb-m2
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutation:    Insertion
 
Mutation detailsTransfecting ES cells containing a floxed 1alpha exon with mice expressing cre recombinase resulted in the excision of the exon, thereby ablating isoform 1A expression. RT-PCR of lung confirmed absence of transcript from the exon, while the 1C isoform remained unaffected. (J:101369)
Phenotypes
Loading...
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Rassf1 Mutation:  12 strains or lines available
References
Original:  J:101369 van der Weyden L, et al., The RASSF1A isoform of RASSF1 promotes microtubule stability and suppresses tumorigenesis. Mol Cell Biol. 2005 Sep;25(18):8356-67
All:  6 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
03/14/2017
MGI 6.08
The Jackson Laboratory