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Tg(Prnp-MAPT*P301L)JNPL3Hlmc
Transgene Detail
Nomenclature
Symbol: Tg(Prnp-MAPT*P301L)JNPL3Hlmc
Name: transgene insertion JNPL3, Mike Hutton
MGI ID: MGI:3604148
Synonyms: JNPL3, P301L, P301L tau 4R, tauP301L, tau (P301L), Tg(Prnp-MAPT*P301L)3Hlmc
Transgene: Tg(Prnp-MAPT*P301L)JNPL3Hlmc  Location: unknown  
Transgene
origin
Strain of Origin:  Not Specified
Transgene
description
Transgene Type:    Transgenic (Humanized sequence, Inserted expressed sequence)
Mutation:    Insertion
 
Tg(Prnp-MAPT*P301L)JNPL3Hlmc expresses 1 gene
 
Mutation detailsThe mouse prion protein promoter was used to drive expression of human microtubule-associated protein tau with a P301L substitution. Hemizygous mice mice expressed the protein at levels roughly equivalent to that of endogenous tau. A largely neuronal expression pattern was shown by in situ hybridization, with strongest signals in the cerebellum and hippocampus, followed by the thalamus, hypothalamus, spinal cord, brainstem and cortex. (J:63887)
Phenotypes
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View phenotypes for all genotypes (concatenated display).
Disease models
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Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Notes
Microinjected into fertilized mouse C57BL/DBA2/SW eggs.

References
Original:  J:63887 Lewis J, et al., Neurofibrillary tangles, amyotrophy and progressive motor disturbance in mice expressing mutant (P301L) tau protein. Nat Genet. 2000 Aug;25(4):402-5
All:  36 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
05/20/2015
MGI 5.22
The Jackson Laboratory