Fgfr2^tm2Cxd
Targeted Allele Detail

Summary

• Symbol: Fgfr2^tm2Cxd
• Name: fibroblast growth factor receptor 2; targeted mutation 2, Chu-Xia Deng
• MGI ID: MGI:3604072
• Synonyms: Fgfr2^neo250, Fgfr2^Neo-S252W
• Gene: Fgfr2 Location: Chr7:129764181-129868538 bp, - strand Genetic Position: Chr7, 73.19 cM
• Alliance: Fgfr2^tm2Cxd page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:101385
• Parent Cell Line: TC1/TC-1 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Conditional ready, Hypomorph)
• Mutation: Nucleotide substitutions
• Mutation details: A targeting vector containing a GG substitution resulted in a Ser250Trp mutation in exon 7. A floxed neo was inserted upstream of exon 7. This allele was a hypomorph, expressed only in significantly reduced levels. Removal of the floxed neo restores expression levels. (J:101385)

Disease models

Expression

In Structures Affected by this Mutation:

14 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Fgfr2 Mutation: 87 strains or lines available

References

• Original: J:101385 Chen L, et al., A Ser250Trp substitution in mouse fibroblast growth factor receptor 2 (Fgfr2) results in craniosynostosis. Bone. 2003 Aug;33(2):169-78
• All: 13 reference(s)