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Targeted Allele Detail
Symbol: Smarcb1tm1Gvk
Name: SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily b, member 1; targeted mutation 1, Ganjam V Kalpana
MGI ID: MGI:3603561
Synonyms: Ini1delta6,7
Gene: Smarcb1  Location: Chr10:75896769-75921617 bp, - strand  Genetic Position: Chr10, 38.61 cM
Smarcb1tm1Gvk/Smarcb1+ mice develop tumors that overexpress Cyclin D1

Show the 1 phenotype image(s) involving this allele.

Germline Transmission:  Earliest citation of germline transmission: J:101185
Parent Cell Line:  WW6 (ES Cell)
Strain of Origin:  STOCK 129/Sv and C57BL/6J and SJL
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsExons 6 and 7 were replaced with a PGK-hygromycin resistance cassette. Immunoblot of total protein from heterozygous mice failed to detect a truncated protein corresponding to the mutant allele, thereby indicating it is most likely a null. (J:101185)
View phenotypes for all genotypes (concatenated display).
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Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Smarcb1 Mutation:  6 strains or lines available
Original:  J:101185 Tsikitis M, et al., Genetic ablation of Cyclin D1 abrogates genesis of rhabdoid tumors resulting from Ini1 loss. Proc Natl Acad Sci U S A. 2005 Aug 23;102(34):12129-34
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 6.0
The Jackson Laboratory