Fgfr2tm1Ewj
Targeted Allele Detail
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Symbol: |
Fgfr2tm1Ewj |
Name: |
fibroblast growth factor receptor 2; targeted mutation 1, Ethylin Wang Jabs |
MGI ID: |
MGI:3603464 |
Synonyms: |
Fgfr2NeoS252W, Fgfr2S252Wflox |
Gene: |
Fgfr2 Location: Chr7:129764181-129868538 bp, - strand Genetic Position: Chr7, 73.19 cM
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Alliance: |
Fgfr2tm1Ewj page
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Skull analysis of Fgfr2tm2Ewj/Fgfr2+ Tg(EIIa-cre)C5379Lmgd/0 and Fgfr2tm1Ewj/Fgfr2+ Tg(EIIa-cre)C5379Lmgd/0 mice
Show the 1 phenotype image(s) involving this allele.
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Allele Type: |
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Targeted (Hypomorph, Modified isoform(s)) |
Mutations: |
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Insertion, Nucleotide substitutions
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Mutation details: A targeting vector containing a 755-756 CA to GG substitution resulted in a Ser252Trp mutation in exon IIIa. A floxed neo was inserted into intron IIIa (exon 7). This allele was a hypomorph and either was not expressed or expressed in reduced levels. Expression of alternative transcripts IIIb and IIIc were reduced by 16% to 41% compared to normal transcripts in multiple tissues tested.
(J:101174)
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View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Carrying any Fgfr2 Mutation: |
87 strains or lines available
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Original: |
J:101174 Wang Y, et al., Abnormalities in cartilage and bone development in the Apert syndrome FGFR2(+/S252W) mouse. Development. 2005 Aug;132(15):3537-48 |
All: |
17 reference(s) |
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