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Gene trapped Allele Detail
Symbol: Slc25a12Gt(OST123999)Lex
Name: solute carrier family 25 (mitochondrial carrier, Aralar), member 12; gene trap OST123999, Lexicon Genetics
MGI ID: MGI:3603462
Synonyms: Aralar-, Slc25a12Gt(neo)1Lex
Gene: Slc25a12  Location: Chr2:71274270-71367554 bp, - strand  Genetic Position: Chr2, 42.38 cM
Mutant Cell Line:  OST123999
Germline Transmission:  Earliest citation of germline transmission: J:101164
Parent Cell Line:  Lex-1 (ES Cell)
Strain of Origin:  129S5/SvEvBrd
Project Collection: Lexicon
Allele Type:    Gene trapped (Null/knockout, Reporter)
Mutation:    Insertion of gene trap vector
Mutation detailsA gene trap vector containing a splice acceptor site and a BTK-neo was inserted into intron 13. Northern blot detected a fusion transcript between the 5' endogenous locus and the neo. Western blot demonstrated lack of endogenous protein in mutants. (J:101164)
Sequence Tags: 
Sequence tag details (1 tag)
Genome Context: 
Genome Browser view of this mutation
View phenotypes and curated references for all genotypes (concatenated display).
Disease models
In Structures Affected by this Mutation: 5 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Slc25a12 Mutation:  102 strains or lines available
Original:  J:101164 Jalil MA, et al., Reduced N-acetylaspartate levels in mice lacking aralar, a brain- and muscle-type mitochondrial aspartate-glutamate carrier. J Biol Chem. 2005 Sep 2;280(35):31333-9
All:  10 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.14
The Jackson Laboratory