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Grm8tm1Duv
Targeted Allele Detail
Nomenclature
Symbol: Grm8tm1Duv
Name: glutamate receptor, metabotropic 8; targeted mutation 1, Robert M Duvoisin
MGI ID: MGI:3603321
Synonyms: mGlu8-, mGluR8-
Gene: Grm8  Location: Chr6:27275118-28135177 bp, - strand  Genetic Position: Chr6, 11.97 cM, cytoband A3
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:101087
Parent Cell Line:  W9.5/W95 (ES Cell)
Strain of Origin:  129S1/Sv-Oca2+ Tyr+ Kitl+
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutation:    Insertion
 
Mutation detailsA neomycin resistance cassette was inserted into exon 8, which encodes six of the seven predicted transmembrane segments. Both splice variants were undetectable by immunoblot. (J:101087)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 1 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Grm8 Mutation:  44 strains or lines available
References
Original:  J:101087 Duvoisin RM, et al., Increased measures of anxiety and weight gain in mice lacking the group III metabotropic glutamate receptor mGluR8. Eur J Neurosci. 2005 Jul;22(2):425-36
All:  7 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
01/12/2022
MGI 6.17
The Jackson Laboratory