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Targeted Allele Detail
Symbol: Errfi1tm1Gvw
Name: ERBB receptor feedback inhibitor 1; targeted mutation 1, George F Vande Woude
MGI ID: MGI:3603195
Synonyms: Mig-6-
Gene: Errfi1  Location: Chr4:150938376-150953349 bp, + strand  Genetic Position: Chr4, 81.5 cM, cytoband E1
Errfi1tm1Gvw/Errfi1tm1Gvw mouse joints display pathological features of osteoarthritis

Show the 4 phenotype image(s) involving this allele.

Germline Transmission:  Earliest citation of germline transmission: J:100927
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsThe entire coding region (exons 2-4) were replaced with a pgk-neomycin resistance gene. Absence of transcript was demonstrated in Northern blot of mutant liver and thymus. (J:100927)
View phenotypes and curated references for all genotypes (concatenated display).
Disease models
In Structures Affected by this Mutation: 1 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Errfi1 Mutation:  15 strains or lines available
Original:  J:100927 Zhang YW, et al., Targeted disruption of Mig-6 in the mouse genome leads to early onset degenerative joint disease. Proc Natl Acad Sci U S A. 2005 Aug 16;102(33):11740-5
All:  5 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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MGI 6.21
The Jackson Laboratory