Bace1^tm1Psa
Targeted Allele Detail

Summary

• Symbol: Bace1^tm1Psa
• Name: beta-site APP cleaving enzyme 1; targeted mutation 1, Paul Saftig
• MGI ID: MGI:3603141
• Synonyms: bace1^-, BACE1I
• Gene: Bace1 Location: Chr9:45749878-45775694 bp, + strand Genetic Position: Chr9, 25.22 cM
• Alliance: Bace1^tm1Psa page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:100925
• Parent Cell Line: MPI-II (ES Cell)
• Strain of Origin: 129S2/SvPas

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• Mutation details: A neomycin expression cassette was inserted into the first coding exon at codon 49, resulting in a premature translational stop codon. Western blot confirmed the absence of protein in mutants. (J:100925)

Expression

In Mice Carrying this Mutation:	2 assay results
In Structures Affected by this Mutation:	2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Bace1 Mutation: 27 strains or lines available

References

• Original: J:100925 Dominguez D, et al., Phenotypic and biochemical analyses of BACE1- and BACE2-deficient mice. J Biol Chem. 2005 Sep 2;280(35):30797-806
• All: 16 reference(s)