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Spred2Gt(XB228)Byg
Gene trapped Allele Detail
Nomenclature
Symbol: Spred2Gt(XB228)Byg
Name: sprouty-related, EVH1 domain containing 2; gene trap XB228, BayGenomics
MGI ID: MGI:3590299
Synonyms: Spred-2-, Spred2Gt(pGTO)1Ksch
Gene: Spred2  Location: Chr11:19924375-20024026 bp, + strand  Genetic Position: Chr11, 12.79 cM, cytoband A3.2
Achondroplasia-like dwarfism in Spred2Gt(XB228)Byg/Spred2Gt(XB228)Byg mice

Show the 2 phenotype image(s) involving this allele.

Mutation
origin
Mutant Cell Line:  XB228 (BayGenomics)
Germline Transmission:  Earliest citation of germline transmission: J:100826
Parent Cell Line:  Other (see notes) (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Gene trapped
Mutation:    Insertion of gene trap vector     Vector: pGT0pfs     Vector Type: gene trap
 
Mutation details
Sequence Tags: 
Sequence tag details (1 tag)
Genome Context: 
Genome Browser view of this mutation
Phenotypes
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Disease models
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Expression
In Mice Carrying this Mutation: 368 assay results
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 1 line available
Carrying any Spred2 Mutation:  202 strains or lines available
Notes
All BayGenomics gene trap mutations were generated in either CGR8 or E14TG2a (129P2/OlaHsd) parental ES cell lines, with the majority in subline E14TG2a.4. The specific ES cell line in which each mutation was made is not specified.

References
Original:  J:100826 Bundschu K, et al., Gene disruption of Spred-2 causes dwarfism. J Biol Chem. 2005 Aug 5;280(31):28572-80
All:  5 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
10/21/2014
MGI 5.20
The Jackson Laboratory