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Gene trapped Allele Detail
Symbol: Spred2Gt(XB228)Byg
Name: sprouty-related EVH1 domain containing 2; gene trap XB228, BayGenomics
MGI ID: MGI:3590299
Synonyms: Spred-2-, Spred2Gt(pGTO)1Ksch
Gene: Spred2  Location: Chr11:19924442-20024026 bp, + strand  Genetic Position: Chr11, 12.79 cM, cytoband A3.2
Achondroplasia-like dwarfism in Spred2Gt(XB228)Byg/Spred2Gt(XB228)Byg mice

Show the 2 phenotype image(s) involving this allele.

Mutant Cell Line:  XB228
Germline Transmission:  Earliest citation of germline transmission: J:100826
Parent Cell Line:  Other (see notes) (ES Cell)
Strain of Origin:  129P2/OlaHsd
Allele Type:    Gene trapped (Null/knockout, Reporter)
Mutation:    Insertion of gene trap vector     Vector: pGT0pfs     Vector Type: gene trap
Mutation detailsA gene trap vector, pGTO, containing a splice acceptor, Betageo and SV40 pA sequence, inserted into intron 4 of the locus. RT-PCR failed to detect transcript in all tissues tested. Northern blot and Western blot confirmed lack of all forms of transcript and protein in mutant brain samples, respectively. (J:100826)
Sequence Tags: 
Sequence tag details (1 tag)
Genome Context: 
Genome Browser view of this mutation
View phenotypes and curated references for all genotypes (concatenated display).
Disease models
In Mice Carrying this Mutation: 368 assay results
In Structures Affected by this Mutation: 5 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Spred2 Mutation:  214 strains or lines available
All BayGenomics gene trap mutations were generated in either CGR8 or E14TG2a (129P2/OlaHsd) parental ES cell lines, with the majority in subline E14TG2a.4. The specific ES cell line in which each mutation was made is not specified.
Original:  J:100826 Bundschu K, et al., Gene disruption of Spred-2 causes dwarfism. J Biol Chem. 2005 Aug 5;280(31):28572-80
All:  7 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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MGI 6.14
The Jackson Laboratory