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Targeted Allele Detail
Symbol: Cflartm1Ywh
Name: CASP8 and FADD-like apoptosis regulator; targeted mutation 1, You-Weh He
MGI ID: MGI:3589399
Synonyms: cflipf, c-FLIPf
Gene: Cflar  Location: Chr1:58711508-58758884 bp, + strand  Genetic Position: Chr1, 29.16 cM
Germline Transmission:  Earliest citation of germline transmission: J:100558
Parent Cell Line:  TC1/TC-1 (ES Cell)
Strain of Origin:  129S6/SvEvTac
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
Mutation detailsA targeting vector was designed to insert loxP sites flanking exon 1, which encodes amino acids 1-98. An FRT-flanked neo cassette was included in the vector and subsequently removed by crossing with mice expressing Flp reocmbinase. (J:100558)
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Cflar Mutation:  4 strains or lines available
Original:  J:100558 Zhang N, et al., An essential role for c-FLIP in the efficient development of mature T lymphocytes. J Exp Med. 2005 Aug 1;202(3):395-404
All:  18 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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MGI 6.16
The Jackson Laboratory