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Baxtm2Sjk
Targeted Allele Detail
Nomenclature
Symbol: Baxtm2Sjk
Name: BCL2-associated X protein; targeted mutation 2, Stanley J Korsmeyer
MGI ID: MGI:3589203
Synonyms: Baxfl
Gene: Bax  Location: Chr7:45461697-45466898 bp, - strand  Genetic Position: Chr7, 29.32 cM, cytoband B5
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:100463
Parent Cell Line:  RW-4 (ES Cell)
Strain of Origin:  129X1/SvJ
Mutation
description
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
 
Mutation detailsLoxP sites were inserted to flank exons 2-4. A loxP-flanked neo was removed via cre-mediated recombination. (J:100463)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Bax Mutation:  25 strains or lines available
References
Original:  J:100463 Takeuchi O, et al., Essential role of BAX,BAK in B cell homeostasis and prevention of autoimmune disease. Proc Natl Acad Sci U S A. 2005 Aug 9;102(32):11272-7
All:  60 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
09/10/2019
MGI 6.14
The Jackson Laboratory