Ducm1^C57BL/6J
QTL Variant Detail

Summary

• QTL variant: Ducm1^C57BL/6J
• Name: dsRNA-induced UCM 1; C57BL/6J
• MGI ID: MGI:3589164
• QTL: Ducm1 Location: unknown Genetic Position: Chr7, cM position of peak correlated region/allele: 31.19 cM
• QTL Note: genome coordinates based on the marker associated with the peak LOD score

Variant origin

• Strain of Specimen: C57BL/6J

Variant description

• Allele Type: QTL
• Inheritance: Recessive

Notes

Mapping and Phenotype information for this QTL, its variants and associated markers

J:86617

57 microsatellite markers were genotyped in a population of (C57BL/6 x 129X1/SvJ)F2 intercross animals to map the gene responsible for dsRNA-induced upregulation of costimulatory molecules (UCM). The segregation pattern of this phenotype follows a 1:3 Mendelian ratio indicating the presence of a single gene locus. This gene is designated Ducm1 (dsRNA-induced UCM 1) and maps to 24.5 cM on mouse Chromosome 7 near D7Mit69 (LOD=5.03).

References

• Original: J:86617 Hoebe K, et al., Upregulation of costimulatory molecules induced by lipopolysaccharide and double-stranded RNA occurs by Trif-dependent and Trif-independent pathways. Nat Immunol. 2003 Dec;4(12):1223-9
• All: 1 reference(s)