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Cd8ts1C3H
QTL Variant Detail
Nomenclature
QTL variant: Cd8ts1C3H
Name: CD8 T cell subset 1; C3H
MGI ID: MGI:3589153
QTL: Cd8ts1  Location: Chr5:44215348-44215451 bp  Genetic Position: Chr5, cM position of peak correlated region/allele: 24.07 cM
QTL Note: genome coordinates based on the marker associated with the peak LOD score
Variant
origin
Strain of Specimen:  C3H
Variant
description
Allele Type:    QTL
Notes

Mapping and Phenotype information for this QTL, its variants and associated markers

J:83220

Interval mapping was performed on a (BALB/c x C57BL/6)F1 x (C3H x DBA/2)F1 cross to identify QTLs affecting the level of T cell subsets in virgin and mated animals at 8 and 18 months of age. A QTL associated with CD8 T cell subset levels, Cd8ts1, mapped to 26 cM (D5Mit79) on mouse Chromosome 5 and a QTL associated with P-glycoprotein positive CD8 T cell subset levels, Pcd8ts1, mapped to 61 cM (D5Mit25) on mouse Chromosome 5 with statistical significance of P<0.05. Cd8ts1 is associated with CD8 T cell levels in 18 month old mated mice. Pcd8ts1 is associated with P-glycoprotein positive CD8 T cell levels in 8 month old mated mice.

References
Original:  J:83220 Jackson AU, et al., Genetic polymorphisms in mouse genes regulating age-sensitive and age-stable T cell subsets. Genes Immun. 2003 Jan;4(1):30-9
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
08/03/2022
MGI 6.21
The Jackson Laboratory