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QTL Variant Detail
QTL variant: Cd8mts1C3H
Name: CD8 T memory cell subset 1; C3H
MGI ID: MGI:3589140
QTL: Cd8mts1  Location: Chr1:172831765-172831892 bp  Genetic Position: Chr1, cM position of peak correlated region/allele: 80.33 cM
QTL Note: genome coordinates based on the marker associated with the peak LOD score
Strain of Specimen:  C3H
Allele Type:    QTL

Mapping and Phenotype information for this QTL, its variants and associated markers


Interval mapping was performed on a (BALB/c x C57BL/6)F1 x (C3H x DBA/2)F1 cross to identify QTLs affecting the level of T cell subsets in virgin and mated animals at 8 and 18 months of age. QTLs associated with CD8 memory T cell subset levels, Cd8mts1 and Cd8mts2, mapped to 95.8 cM (D1Mit206) and 59 cM (D1Nds2), respectively, on mouse Chromosome 1 with statistical significance of P<0.05. Cd8mts1 is associated with CD8 memory T cell levels in 8 month old virgin mice and 18 month old mated mice. Cd8mts2 is associated with CD8 memory T cell levels in 8 month old mated mice.

Original:  J:83220 Jackson AU, et al., Genetic polymorphisms in mouse genes regulating age-sensitive and age-stable T cell subsets. Genes Immun. 2003 Jan;4(1):30-9
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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MGI 6.21
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