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Lmnatm1Lgf
Targeted Allele Detail
Nomenclature
Symbol: Lmnatm1Lgf
Name: lamin A; targeted mutation 1, Loren G Fong
MGI ID: MGI:3587791
Synonyms: LmnaHG
Gene: Lmna  Location: Chr3:88481148-88509956 bp, - strand  Genetic Position: Chr3, 38.84 cM
Lmnatm1Lgf/Lmnatm1Lgf mice are small and have poorly mineralized bone

Show the 5 phenotype image(s) involving this allele.

Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:100220
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation details
Phenotypes
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View phenotypes for all genotypes (concatenated display).
Disease models
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Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Lmna Mutation:  59 strains or lines available
References
Original:  J:100220 Yang SH, et al., Blocking protein farnesyltransferase improves nuclear blebbing in mouse fibroblasts with a targeted Hutchinson-Gilford progeria syndrome mutation. Proc Natl Acad Sci U S A. 2005 Jul 19;102(29):10291-6
All:  6 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
12/16/2014
MGI 5.20
The Jackson Laboratory