About   Help   FAQ
The MGI survey is now closed.
Thanks for your support!
Targeted Allele Detail
Symbol: Hfe2tm1Nca
Name: hemochromatosis type 2 (juvenile) (human homolog); targeted mutation 1, Nancy C Andrews
MGI ID: MGI:3587746
Synonyms: Hfe2-, Hjv-
Gene: Hfe2  Location: Chr3:96525185-96529216 bp, + strand  Genetic Position: Chr3, 41.91 cM
Histological examination of iron loading in Hfe2tm1Nca/Hfe2tm1Nca mice

Show the 1 phenotype image(s) involving this allele.

Germline Transmission:  Earliest citation of germline transmission: J:100178
Parent Cell Line:  J1 (ES Cell)
Strain of Origin:  129S4/SvJae
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsExon 3 and the coding sequence in exon 4 were replaced upon the insertion of a floxed neo cassette, therefore deleting most of the coding sequence for the protein. (J:100178)
View phenotypes for all genotypes (concatenated display).
Disease models
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Hfe2 Mutation:  4 strains or lines available
Original:  J:100178 Huang FW, et al., A mouse model of juvenile hemochromatosis. J Clin Invest. 2005 Aug 1;115(8):2187-2191
All:  12 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
MGI 5.21
The Jackson Laboratory