Col8a2^tm1Bjro
Targeted Allele Detail

Summary

• Symbol: Col8a2^tm1Bjro
• Name: collagen, type VIII, alpha 2; targeted mutation 1, Bjorn R Olsen
• MGI ID: MGI:3587617
• Synonyms: Col8a2^-
• Gene: Col8a2 Location: Chr4:126180587-126208123 bp, + strand Genetic Position: Chr4, 60.29 cM
• Alliance: Col8a2^tm1Bjro page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:100136
• Parent Cell Line: J1 (ES Cell)
• Strain of Origin: 129S4/SvJae

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• Mutation details: A PGK driven neomycin resistance gene was inserted into exon 1. Northern blot of mutants detected no transcripts. (J:100136)

Disease models

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Col8a2 Mutation: 19 strains or lines available

References

• Original: J:100136 Hopfer U, et al., Targeted disruption of Col8a1 and Col8a2 genes in mice leads to anterior segment abnormalities in the eye. FASEB J. 2005 Aug;19(10):1232-44
• All: 7 reference(s)