About   Help   FAQ
Mastr129S4/SvJae
QTL Variant Detail
Nomenclature
QTL variant: Mastr129S4/SvJae
Name: modifier of astrocytoma; 129S4/SvJae
MGI ID: MGI:3587058
QTL: Mastr  Location: Chr11:45817754-89927907 bp  Genetic Position: Chr11, Syntenic
Variant
origin
Strain of Specimen:  129S4/SvJae
Variant
description
Allele Type:    QTL
Mutation:    Undefined
    This allele confers astrocytoma resistance compared to C57BL/6J. (J:92444)
Phenotypes
Loading...
View phenotypes and curated references for all genotypes (concatenated display).
Notes

Mapping and Phenotype information for this QTL, its variants and associated markers

J:92444

Susceptibility to astrocytoma was investigated in NPcis mice on a C57BL/6J background. NPcix are informative because they carry alleles which modify the effects of mutant Nf1 and Trp53 genes in the development of astrocytoma which is similar to strain 129S4/SvJae. A region between D11Mit271 and D11Mit285 was indicated as including genes which may have a modifying effect on the progression of astrocytoma. SNP analysis showed as many as 41 potential candidate genes within the Mastr region.

References
Original:  J:92444 Reilly KM, et al., Susceptibility to astrocytoma in mice mutant for Nf1 and Trp53 is linked to chromosome 11 and subject to epigenetic effects. Proc Natl Acad Sci U S A. 2004 Aug 31;101(35):13008-13
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
11/10/2020
MGI 6.16
The Jackson Laboratory