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Park7tm1Xz
Targeted Allele Detail
Summary
Symbol: Park7tm1Xz
Name: Parkinson disease (autosomal recessive, early onset) 7; targeted mutation 1, Xiaoxi Zhuang
MGI ID: MGI:3586448
Synonyms: DJ-1-
Gene: Park7  Location: Chr4:150981590-150994378 bp, - strand  Genetic Position: Chr4, 81.52 cM, cytoband E1
Alliance: Park7tm1Xz page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:99905
Parent Cell Line:  E14TG2a.4 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA PGK-neo cassette flanked by FRT sites replaced the first five exons and part of the promoter. RT-PCR confirmed absence of transcript in mutant skin fibroblasts. (J:99905)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Park7 Mutation:  53 strains or lines available
References
Original:  J:99905 Chen L, et al., Age-dependent motor deficits and dopaminergic dysfunction in DJ-1 null mice. J Biol Chem. 2005 Jun 3;280(22):21418-26
All:  12 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/12/2024
MGI 6.23
The Jackson Laboratory