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Ilf3tm1Pnk
Targeted Allele Detail
Nomenclature
Symbol: Ilf3tm1Pnk
Name: interleukin enhancer binding factor 3; targeted mutation 1, Peter N Kao
MGI ID: MGI:3586304
Synonyms: NF90-
Gene: Ilf3  Location: Chr9:21368019-21405361 bp, + strand  Genetic Position: Chr9, 7.78 cM, cytoband A4-A5
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:99935
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA neomycin resistance gene replaced exons 2-4, resulting in the deletion of the ATG codon and the introduction of a frameshift that disrupted the ORF. Northern blot of mutants confirmed recombination, and Western blot demonstrated complete lack of protein in mutants. (J:99935)
Phenotypes
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Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Ilf3 Mutation:  65 strains or lines available
References
Original:  J:99935 Shi L, et al., NF90 regulates cell cycle exit and terminal myogenic differentiation by direct binding to the 3'-untranslated region of MyoD and p21WAF1/CIP1 mRNAs. J Biol Chem. 2005 May 13;280(19):18981-9
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/12/2016
MGI 6.04
The Jackson Laboratory