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Tg(Amelx)42Msnd
Transgene Detail
Nomenclature
Symbol: Tg(Amelx)42Msnd
Name: transgene insertion 42, Malcolm L Snead
MGI ID: MGI:3584497
Synonyms: M180deltaA-FLAG
Transgene: Tg(Amelx)42Msnd  Location: unknown  
Transgene
origin
Strain of Origin:  (C57BL/6J x DBA/2J)F1 x CBA/J
Transgene
description
Transgene Type:    Transgenic (Inserted expressed sequence)
Mutation:    Insertion
 
Mutation details
Phenotypes
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Disease models
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Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Notes
In situ hybridization with a luciferase cDNA probe detects transgene mRNA only in ameloblasts. Immunohistochemical analysis of four day old incisors using antibodies to the FLAG epitope finds tagged amelogenin restricted to ameloblasts, where it is localized to the cytoplasm, and in the secreted organic enamel matrix. (J:100004)

Several independent founder lines generated from this construct were established; no differences were noted among their phenotypes, and no distinction was made among them.

References
Original:  J:100004 Paine ML, et al., Enamel biomineralization defects result from alterations to amelogenin self-assembly. J Struct Biol. 2000 Dec;132(3):191-200
All:  6 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
09/23/2014
MGI 5.19
The Jackson Laboratory