About   Help   FAQ
Polgtm1.2Lrsn
Targeted Allele Detail
Nomenclature
Symbol: Polgtm1.2Lrsn
Name: polymerase (DNA directed), gamma; targeted mutation 1.2, Nils-Goran Larsson
MGI ID: MGI:3584444
Synonyms: PolgA-
Gene: Polg  Location: Chr7:79446231-79466362 bp, - strand  Genetic Position: Chr7, 45.04 cM, cytoband E
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:99794
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutation:    Intragenic deletion
 
Mutation detailsMice carrying the floxed allele Polgtm1Lrsn were crossed with mice expressing cre ubiquitously, causing the removal of exon 3. Deletion of exon 3 results in a frameshift mutation leading to a stop codon early in exon 4 and the loss of nearly all active domains of the locus. (J:99794)
Phenotypes
Loading...
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Polg Mutation:  36 strains or lines available
References
Original:  J:99794 Hance N, et al., Mitochondrial DNA polymerase gamma is essential for mammalian embryogenesis. Hum Mol Genet. 2005 Jul 1;14(13):1775-83
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
10/10/2017
MGI 6.10
The Jackson Laboratory