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Targeted Allele Detail
Symbol: Polgtm1.2Lrsn
Name: polymerase (DNA directed), gamma; targeted mutation 1.2, Nils-Goran Larsson
MGI ID: MGI:3584444
Synonyms: PolgA-
Gene: Polg  Location: Chr7:79446231-79466362 bp, - strand  Genetic Position: Chr7, 45.04 cM, cytoband E
Germline Transmission:  Earliest citation of germline transmission: J:99794
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Allele Type:    Targeted (Null/knockout)
Mutation:    Intragenic deletion
Mutation detailsMice carrying the floxed allele Polgtm1Lrsn were crossed with mice expressing cre ubiquitously, causing the removal of exon 3. Deletion of exon 3 results in a frameshift mutation leading to a stop codon early in exon 4 and the loss of nearly all active domains of the locus. (J:99794)
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Polg Mutation:  36 strains or lines available
Original:  J:99794 Hance N, et al., Mitochondrial DNA polymerase gamma is essential for mammalian embryogenesis. Hum Mol Genet. 2005 Jul 1;14(13):1775-83
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 6.11
The Jackson Laboratory