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Nos1tm1Enik
Targeted Allele Detail
Nomenclature
Symbol: Nos1tm1Enik
Name: nitric oxide synthase 1, neuronal; targeted mutation 1, Grigori Enikolopov
MGI ID: MGI:3584262
Gene: Nos1  Location: Chr5:117781032-117958840 bp, + strand  Genetic Position: Chr5, 57.29 cM, cytoband F
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:99879
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129X1/SvJ
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA neomycin resistance gene replaced 628 bp encompassing exon 6 and adjacent intronic sequences. RT-PCR of mutants confirmed absence of transcript in mutants and Western blot demonstrated absence of protein from both C- and N-terminal sequences. (J:99879)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Nos1 Mutation:  38 strains or lines available
References
Original:  J:99879 Packer MA, et al., Nitric oxide negatively regulates mammalian adult neurogenesis. Proc Natl Acad Sci U S A. 2003 Aug 5;100(16):9566-71
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/11/2017
MGI 6.10
The Jackson Laboratory