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Man2b1tm1Psa
Targeted Allele Detail
Summary
Symbol: Man2b1tm1Psa
Name: mannosidase 2, alpha B1; targeted mutation 1, Paul Saftig
MGI ID: MGI:3584185
Synonyms: alpha-Man-
Gene: Man2b1  Location: Chr8:85809899-85824911 bp, + strand  Genetic Position: Chr8, 41.55 cM, cytoband C2
Alliance: Man2b1tm1Psa page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:56659
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutation:    Insertion
 
Mutation detailsA neomycin resistance gene was inserted into exon 2, resulting in a premature stop codon in the ORF. The complete absence of transcript in mutants was confirmed by Northern blot and RT-PCR analyses. (J:56659)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Structures Affected by this Mutation: 24 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Man2b1 Mutation:  45 strains or lines available
References
Original:  J:56659 Stinchi S, et al., Targeted disruption of the lysosomal alpha-mannosidase gene results in mice resembling a mild form of human alpha-mannosidosis. Hum Mol Genet. 1999 Aug;8(8):1365-72
All:  4 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/12/2024
MGI 6.23
The Jackson Laboratory