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Pak3tm1Zpj
Targeted Allele Detail
Nomenclature
Symbol: Pak3tm1Zpj
Name: p21 (RAC1) activated kinase 3; targeted mutation 1, Zhengping Jia
MGI ID: MGI:3584167
Synonyms: PAK3-
Gene: Pak3  Location: ChrX:143518591-143797796 bp, + strand  Genetic Position: ChrX, 64.5 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:99811
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA targeting vector containing a pgk-neo cassette was designed to eliminate the region encoding the entire kinase domain. Protein was undetected in Western blot analyses of mutant brain lysates. (J:99811)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Pak3 Mutation:  21 strains or lines available
References
Original:  J:99811 Meng J, et al., Abnormal long-lasting synaptic plasticity and cognition in mice lacking the mental retardation gene Pak3. J Neurosci. 2005 Jul 13;25(28):6641-50
All:  4 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
02/11/2020
MGI 6.14
The Jackson Laboratory