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Bcl6btm1Dtf
Targeted Allele Detail
Nomenclature
Symbol: Bcl6btm1Dtf
Name: B cell CLL/lymphoma 6, member B; targeted mutation 1, Douglas T Fearson
MGI ID: MGI:3584139
Synonyms: Bcl5b-
Gene: Bcl6b  Location: Chr11:70224128-70229798 bp, - strand  Genetic Position: Chr11, 42.99 cM, cytoband B4
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:99818
Parent Cell Line:  E14 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA targeting construct was designed such that nucleotides 14-114 of exon 2, encoding codons 1-33, were replaced with a human CD2 reporter cDNA and a loxP-flanked neomycin resistance gene in reverse orientation. Three copies of the SV40 poly A signal were inserted into exon 3. The first downstream in-frame methionine was at codon 119, distal to the poxvirus and zinc finger domain. Northern blot of mutant lung samples revealed a truncated transcript of 0.53 kb, and that the inserted sequence altered the normal splicing of the transcript. (J:99818)
Phenotypes
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Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Bcl6b Mutation:  2 strains or lines available
References
Original:  J:99818 Manders PM, et al., BCL6b mediates the enhanced magnitude of the secondary response of memory CD8+ T lymphocytes. Proc Natl Acad Sci U S A. 2005 May 24;102(21):7418-25
All:  1 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
11/22/2016
MGI 6.06
The Jackson Laboratory