About   Help   FAQ
Bcl6btm1Dtf
Targeted Allele Detail
Nomenclature
Symbol: Bcl6btm1Dtf
Name: B cell CLL/lymphoma 6, member B; targeted mutation 1, Douglas T Fearson
MGI ID: MGI:3584139
Synonyms: Bcl5b-
Gene: Bcl6b  Location: Chr11:70224128-70229798 bp, - strand  Genetic Position: Chr11, 42.99 cM, cytoband B4
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:99818
Parent Cell Line:  E14 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA targeting construct was designed such that nucleotides 14-114 of exon 2, encoding codons 1-33, were replaced with a human CD2 reporter cDNA and a loxP-flanked neomycin resistance gene in reverse orientation. Three copies of the SV40 poly A signal were inserted into exon 3. The first downstream in-frame methionine was at codon 119, distal to the poxvirus and zinc finger domain. Northern blot of mutant lung samples revealed a truncated transcript of 0.53 kb, and that the inserted sequence altered the normal splicing of the transcript. (J:99818)
Phenotypes
Loading...
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Bcl6b Mutation:  5 strains or lines available
References
Original:  J:99818 Manders PM, et al., BCL6b mediates the enhanced magnitude of the secondary response of memory CD8+ T lymphocytes. Proc Natl Acad Sci U S A. 2005 May 24;102(21):7418-25
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
12/05/2017
MGI 6.11
The Jackson Laboratory