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Polgtm1Prol
Targeted Allele Detail
Nomenclature
Symbol: Polgtm1Prol
Name: polymerase (DNA directed), gamma; targeted mutation 1, Tomas A Prolla
MGI ID: MGI:3583920
Synonyms: mtDNA-mutator, PolgA, PolgAD257A, Polgm, Polgmut, Polgtm1Tprol
Gene: Polg  Location: Chr7:79446231-79466362 bp, - strand  Genetic Position: Chr7, 45.04 cM, cytoband E
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:99764
Parent Cell Line:  AB2.2 (ES Cell)
Strain of Origin:  129S7/SvEvBrd-Hprtb-m2
Mutation
description
Allele Type:    Targeted (Not Specified)
Mutation:    Nucleotide substitutions
 
Mutation detailsA targeting construct was designed to introduce an AC to CT two-base substitution in positions 1054 and 1055, resulting in a critical residue substitution in the conserved exonuclease domain (D257A). (J:99764)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Structures Affected by this Mutation: 10 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Polg Mutation:  38 strains or lines available
References
Original:  J:99764 Kujoth GC, et al., Mitochondrial DNA mutations, oxidative stress, and apoptosis in mammalian aging. Science. 2005 Jul 15;309(5733):481-4
All:  37 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
04/13/2021
MGI 6.16
The Jackson Laboratory