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Ptk2tm1.2Guan
Targeted Allele Detail
Nomenclature
Symbol: Ptk2tm1.2Guan
Name: PTK2 protein tyrosine kinase 2; targeted mutation 1.2, Jun-Lin Guan
MGI ID: MGI:3583807
Synonyms: FAKdelta
Gene: Ptk2  Location: Chr15:73205102-73423280 bp, - strand  Genetic Position: Chr15, 33.94 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:99637
Parent Cell Line:  E14.1 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutation:    Intragenic deletion
 
Mutation detailsExon 3 was deleted via cre-mediated excision, resulting in a frame-shift mutation and the direct splicing of exon 2 to exon 4, and the production of a truncated protein of approximately 70 amino acids. Western blot of E8.5 lysates confirmed absence of protein in embryos. (J:99637)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 8 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Ptk2 Mutation:  70 strains or lines available
References
Original:  J:99637 Shen TL, et al., Conditional knockout of focal adhesion kinase in endothelial cells reveals its role in angiogenesis and vascular development in late embryogenesis. J Cell Biol. 2005 Jun 20;169(6):941-52
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
02/18/2020
MGI 6.14
The Jackson Laboratory