About   Help   FAQ
Rbpjtm1Hon
Targeted Allele Detail
Summary
Symbol: Rbpjtm1Hon
Name: recombination signal binding protein for immunoglobulin kappa J region; targeted mutation 1, Tasuku Honjo
MGI ID: MGI:3583755
Synonyms: RBPf, RBP-JC, RBP-Jf, Rbpjflox, Rbp-Jflox, RBP-JkappaFl, RBP-Jkappaflox, RBPJkappaloxP, RBP-Jlox, RbpjloxP, Rbpsuhtm3Kyo
Gene: Rbpj  Location: Chr5:53713121-53814787 bp, + strand  Genetic Position: Chr5, 29.37 cM, cytoband C1-C3
Alliance: Rbpjtm1Hon page
The number of melanocyte lineage cells is dramatically reduced in Rbpjtm1Hon Rbpjtm1Hon Tg(Tyr-cre)#Lru/0 mice

Show the 2 phenotype image(s) involving this allele.

Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:99747
Parent Cell Line:  E14 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
 
Mutation detailsLoxP sites were inserted to flank exon 6, which encodes the DNA binding domain, and exon 7. In addition, a neomycin resistance gene was inserted between exon 7 and the 3' loxP site. (J:99747)
Phenotypes
Loading...
View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 52390 assay results
14 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation: 30 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any Rbpj Mutation:  193 strains or lines available
References
Original:  J:99747 Han H, et al., Inducible gene knockout of transcription factor recombination signal binding protein-J reveals its essential role in T versus B lineage decision. Int Immunol. 2002 Jun;14(6):637-45
All:  332 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support.
last database update
03/12/2024
MGI 6.23
The Jackson Laboratory