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Targeted Allele Detail
Symbol: Rbpjtm1Hon
Name: recombination signal binding protein for immunoglobulin kappa J region; targeted mutation 1, Tasuku Honjo
MGI ID: MGI:3583755
Synonyms: RBPf, RBP-JC, RBP-Jf, Rbpjflox, Rbp-Jflox, RBP-JkappaFl, RBP-Jkappaflox, RBPJkappaloxP, RBP-Jlox, RbpjloxP, Rbpsuhtm3Kyo
Gene: Rbpj  Location: Chr5:53713121-53814787 bp, + strand  Genetic Position: Chr5, 29.37 cM, cytoband C1-C3
The number of melanocyte lineage cells is dramatically reduced in Rbpjtm1Hon Rbpjtm1Hon Tg(Tyr-cre)#Lru/0 mice

Show the 2 phenotype image(s) involving this allele.

Germline Transmission:  Earliest citation of germline transmission: J:99747
Parent Cell Line:  E14 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
Mutation detailsLoxP sites were inserted to flank exon 6, which encodes the DNA binding domain, and exon 7. In addition, a neomycin resistance gene was inserted between exon 7 and the 3' loxP site. (J:99747)
View phenotypes and curated references for all genotypes (concatenated display).
In Mice Carrying this Mutation: 52058 assay results
In Structures Affected by this Mutation: 30 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any Rbpj Mutation:  202 strains or lines available
Original:  J:99747 Han H, et al., Inducible gene knockout of transcription factor recombination signal binding protein-J reveals its essential role in T versus B lineage decision. Int Immunol. 2002 Jun;14(6):637-45
All:  316 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.21
The Jackson Laboratory