About   Help   FAQ
Spontaneous Allele Detail
Symbol: Npr2cn-3J
Name: natriuretic peptide receptor 2; achondroplasia 3 Jackson
MGI ID: MGI:3583746
Gene: Npr2  Location: Chr4:43631935-43651244 bp, + strand  Genetic Position: Chr4, 23.05 cM
Disproportionate dwarf phenotype in Npr2cn-3J/Npr2cn-3J mice

Show the 1 phenotype image(s) involving this allele.

Strain of Origin:  MRL/MpJ-Faslpr/J
Allele Type:    Spontaneous (Not Specified)
Mutation:    Single point mutation
Mutation detailsA failed complementation test of this spontaneous mutant with the Npr2cn-2J allele demonstrated that this mutation is an allele of Npr2, and a G to A transition was identified in Chromosome 4 position 43669099 bp (MGSCv37), which is in exon 19 and is predicted to encode an alanine to threonine substitution at amino acid 931. (J:170669)
Inheritance:    Recessive
View phenotypes for all genotypes (concatenated display).
Disease models
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Npr2 Mutation:  9 strains or lines available
Original:  J:170669 Karst SY, et al., A remutation to achondroplasia in the MRL/MpJ inbred background: Npr2cn-3J. MGI Direct Data Submission. 2011;
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
MGI 6.0
The Jackson Laboratory