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Targeted Allele Detail
Symbol: Psen1tm1Tak
Name: presenilin 1; targeted mutation 1, Junji Takeda
MGI ID: MGI:3583662
Synonyms: mPS1, PS1 I213T, PS1/I213T
Gene: Psen1  Location: Chr12:83688152-83735199 bp, + strand  Genetic Position: Chr12, 38.84 cM
Germline Transmission:  Earliest citation of germline transmission: J:56247
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Allele Type:    Targeted
Mutation:    Insertion
Mutation detailsThe I213T mutation was inserted into exon 7. A neomycin resistance (Neo) gene flanked by two loxP sites was inserted into intron 6 for selection and was removed via cre-mediated recombination. Northern blot and RT-PCR demonstrated that the levels of transcript in mutants were comparable to that in wild-type. Elevated levels of the amyloid beta peptide 42 were dected in homozygous mice. (J:56247)
View phenotypes and curated references for all genotypes (concatenated display).
Disease models
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Psen1 Mutation:  35 strains or lines available
Original:  J:56247 Nakano Y, et al., Accumulation of murine amyloidbeta42 in a gene-dosage-dependent manner in PS1 'knock-in' mice. Eur J Neurosci. 1999 Jul;11(7):2577-81
All:  7 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 6.11
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