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Tg(Ins1-EGFP/GH1)14Hara
Transgene Detail
Nomenclature
Symbol: Tg(Ins1-EGFP/GH1)14Hara
Name: transgene insertion 14, Manami Hara
MGI ID: MGI:3583654
Synonyms: MIP-GFP, NOD-MIP-GFP
Transgene: Tg(Ins1-EGFP/GH1)14Hara  Location: unknown  
Transgene
origin
Strain of Origin:  NOD/ShiLtJ
Transgene
description
Transgene Type:    Transgenic (Reporter)
Mutation:    Insertion
 
Mutation detailsThe transgene comprises a DNA fragment containing the mouse insulin 1 promoter, extending from 8.5 kb upstream of the transcription initiation site to nucleotide +12, driving expression of a fusion gene joining the 7.6-kb coding region of the enhanced green fluorescent protein (EGFP) gene to a 2.1-kb fragment of the human growth hormone 1 gene that confers high-level expression. (J:99450)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 1 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Notes
Transgenic mice develop normally and exhibit glucose tolerance and pancreatic insulin levels similar to those of controls. Histological analysis reveals normal islet architecture and coexpression of insulin and EGFP (J:100005)
References
Original:  J:100005 Hara M, NOD transgenic mice with green fluorescent protein-labeled pancreatic beta cells. MGI Direct Data Submission. 2005;
All:  9 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
09/22/2020
MGI 6.16
The Jackson Laboratory