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Ddit4tm1Lwe
Targeted Allele Detail
Nomenclature
Symbol: Ddit4tm1Lwe
Name: DNA-damage-inducible transcript 4; targeted mutation 1, Leif W Ellisen
MGI ID: MGI:3583650
Synonyms: REDD1-
Gene: Ddit4  Location: Chr10:59949675-59951770 bp, - strand  Genetic Position: Chr10, 29.66 cM, cytoband B3
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:99368
Parent Cell Line:  J1 (ES Cell)
Strain of Origin:  129S4/SvJae
Mutation
description
Allele Type:    Targeted (Null/knockout, Reporter)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsThe entire coding region and the 3' UTR were replaced with a betagalactosidase-neomycin fusion protein. Northern blot and Western blot of mutant MEFs confirmed absence of transcript and protein, respectively. (J:99368)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Ddit4 Mutation:  5 strains or lines available
References
Original:  J:99368 Sofer A, et al., Regulation of mTOR and Cell Growth in Response to Energy Stress by REDD1. Mol Cell Biol. 2005 Jul;25(14):5834-45
All:  4 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
03/31/2020
MGI 6.15
The Jackson Laboratory