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Targeted Allele Detail
Symbol: Vezf1tm1Stmn
Name: vascular endothelial zinc finger 1; targeted mutation 1, Heidi Stuhlmann
MGI ID: MGI:3583268
Synonyms: Vezf1-
Gene: Vezf1  Location: Chr11:88068279-88084729 bp, + strand  Genetic Position: Chr11, 52.4 cM
Germline Transmission:  Earliest citation of germline transmission: J:99326
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsA targeting vector replaced exon 1 and the proximal part of the first intron with a promoter-less IRES-lacZgt1.2neo cassette. The deletion included 91 bp upstream of the transcriptional start site, resulting in a null allele. Protein expression was reduced in heterozygous and undetectable in homozygous mutant embryos. (J:99326)
View phenotypes and curated references for all genotypes (concatenated display).
In Mice Carrying this Mutation: 56 assay results
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Vezf1 Mutation:  18 strains or lines available
Original:  J:99326 Kuhnert F, et al., Dosage-dependent requirement for mouse Vezf1 in vascular system development. Dev Biol. 2005 Jul 1;283(1):140-156
All:  4 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 6.11
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