About   Help   FAQ
Hcn2trls
Spontaneous Allele Detail
Summary
Symbol: Hcn2trls
Name: hyperpolarization-activated, cyclic nucleotide-gated K+ 2; tremor and reduced lifespan
MGI ID: MGI:3582957
Gene: Hcn2  Location: Chr10:79552468-79571942 bp, + strand  Genetic Position: Chr10, 39.72 cM, cytoband C1
Alliance: Hcn2trls page
Mutation
origin
Strain of Origin:  BKS.Cg-Dock7m +/+ Leprdb/J
Mutation
description
Allele Type:    Spontaneous
Mutation:    Single point mutation
 
Mutation detailsThis spontaneous mutation has a G-to-A transition at chromosome 10 position 79,724,780 (GRCm38) that causes an arginine to glutamine substitution at residue 315 (p.R315Q). (J:187506, J:222308)
Inheritance:    Recessive
Phenotypes
Loading...
View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 1 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Hcn2 Mutation:  29 strains or lines available
References
Original:  J:103185 Samples R, et al., Tremor and reduced lifespan (trls): a new neurological mutation on Chromosome 10. MGI Direct Data Submission. 2005;
All:  4 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support.
last database update
03/19/2024
MGI 6.23
The Jackson Laboratory