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Bdnftm1Krj
Targeted Allele Detail
Nomenclature
Symbol: Bdnftm1Krj
Name: brain derived neurotrophic factor; targeted mutation 1, Kevin R Jones
MGI ID: MGI:3582638
Synonyms: Bdnfklox, BDNFlox, BDNF-loxp, BDNF-LSL-LacZ
Gene: Bdnf  Location: Chr2:109674700-109727007 bp, + strand  Genetic Position: Chr2, 56.63 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:84683
Parent Cell Line:  D3 (ES Cell)
Strain of Origin:  129S2/SvPas
Mutation
description
Allele Type:    Targeted (Conditional ready, No functional change, Reporter)
Mutation:    Insertion
 
Mutation detailsA targeting construct was designed to flank the pro encoding region and mature hormone-encoding region of exon V with loxP sites, with a trimerized polyadenylation signal upstream of the 3' loxP sequence and a lacZ gene and FRT-flanked neomycin resistance cassette downstream of the 3' loxP sequence. Cre mediated excision would enable transcription and translation of lacZ in place of Bdnf. (J:84683)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 7 assay results
In Structures Affected by this Mutation: 8 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Bdnf Mutation:  27 strains or lines available
References
Original:  J:84683 Gorski JA, et al., Brain-derived neurotrophic factor is required for the maintenance of cortical dendrites. J Neurosci. 2003 Jul 30;23(17):6856-65
All:  25 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
09/15/2020
MGI 6.15
The Jackson Laboratory