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Cyp11b2tm1Hsk
Targeted Allele Detail
Nomenclature
Symbol: Cyp11b2tm1Hsk
Name: cytochrome P450, family 11, subfamily b, polypeptide 2; targeted mutation 1, Hyung-Suk Kim
MGI ID: MGI:3582593
Synonyms: AS-, Cyp11b2tm1Unc
Gene: Cyp11b2  Location: Chr15:74851010-74856318 bp, - strand  Genetic Position: Chr15, 34.29 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:99269
Parent Cell Line:  TC1/TC-1 (ES Cell)
Strain of Origin:  129S6/SvEvTac
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsAn EGFP-neo cassette replaced exons 1 and 2 and the 5' part of exon 3. Transcript was undetected in RT-PCR analysis of mutant adrenal gland samples. (J:99269)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Cyp11b2 Mutation:  19 strains or lines available
References
Original:  J:99269 Lee G, et al., Homeostatic responses in the adrenal cortex to the absence of aldosterone in mice. Endocrinology. 2005 Jun;146(6):2650-6
All:  14 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
10/10/2017
MGI 6.10
The Jackson Laboratory