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Itgaltm1Hlz
Targeted Allele Detail
Nomenclature
Symbol: Itgaltm1Hlz
Name: integrin alpha L; targeted mutation 1, Bernhard Holzmann
MGI ID: MGI:3582587
Synonyms: Lfa-1d
Gene: Itgal  Location: Chr7:127296260-127335138 bp, + strand  Genetic Position: Chr7, 69.44 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:99286
Parent Cell Line:  E14.1 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA constitutive germline deletion of the amino acid motif GFFKR in the membrane proximal segment of the cytoplasmic domain, was accomplished by insertion of a neomycin resistance cassette and a HSV-thymidine kinase cassette. The neo was later removed by crossing to a cre expressing strain. (J:99286)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 1 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Itgal Mutation:  46 strains or lines available
References
Original:  J:99286 Semmrich M, et al., Importance of integrin LFA-1 deactivation for the generation of immune responses. J Exp Med. 2005 Jun 20;201(12):1987-98
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
04/06/2021
MGI 6.16
The Jackson Laboratory