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Targeted Allele Detail
Symbol: Tnfrsf14tm1Kpf
Name: tumor necrosis factor receptor superfamily, member 14 (herpesvirus entry mediator); targeted mutation 1, Klaus Pfeffer
MGI ID: MGI:3582550
Synonyms: HVEM-
Gene: Tnfrsf14  Location: Chr4:154921933-154928563 bp, - strand  Genetic Position: Chr4, 85.81 cM
Germline Transmission:  Earliest citation of germline transmission: J:99456
Parent Cell Line:  E14.1 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsExons 2, 3, and the 5' region of exon 4 were replaced by an intron gene trap cassette encompassing an engrailed-2 splice acceptor sequence, a beta-gal cassette, and a neomycin gene resistance cassette. Northern blot analysis of RNA from splenic tissues confirmed the null mutation. (J:99456)
View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Tnfrsf14 Mutation:  11 strains or lines available
Original:  J:99456 Wang Y, et al., The role of herpesvirus entry mediator as a negative regulator of T cell-mediated responses. J Clin Invest. 2005 Mar;115(3):711-7
All:  26 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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MGI 6.14
The Jackson Laboratory