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Abcc3tm1Bor
Targeted Allele Detail
Nomenclature
Symbol: Abcc3tm1Bor
Name: ATP-binding cassette, sub-family C (CFTR/MRP), member 3; targeted mutation 1, Piet Borst
MGI ID: MGI:3582301
Synonyms: Mrp3-
Gene: Abcc3  Location: Chr11:94234121-94283823 bp, - strand  Genetic Position: Chr11, 58.9 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:149653
Parent Cell Line:  E14 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation details4.9 kb of sequence containing exons 2-8, encoding amino acids 16-331, was replaced with a hygromycin resistance gene driven by Pgk1, and resulted in a frame shift that led to an early stop codon immediately after exon 1. Immunoblotting of various tissues in mutants demonstrated the absence of protein. (J:99480, J:149653)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Abcc3 Mutation:  39 strains or lines available
References
Original:  J:149653 Zelcer N, et al., Mice lacking Mrp3 (Abcc3) have normal bile salt transport, but altered hepatic transport of endogenous glucuronides. J Hepatol. 2006 Apr;44(4):768-75
All:  7 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
01/18/2022
MGI 6.17
The Jackson Laboratory