E2f6^tm1Hgmr
Targeted Allele Detail

Summary

• Symbol: E2f6^tm1Hgmr
• Name: E2F transcription factor 6; targeted mutation 1, Christian Hagemeier
• MGI ID: MGI:3582265
• Synonyms: E2F6^-
• Gene: E2f6 Location: Chr12:16860932-16876753 bp, + strand Genetic Position: Chr12, 8.04 cM
• Alliance: E2f6^tm1Hgmr page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:99185
• Parent Cell Line: E14.1 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Translation termination codons were introduced in all three ORFs after codon 58. A neomycin resistance gene replaced the sequence encoding the DNA binding domain. Western blot analysis confirmed lack of expression in mutants. (J:99185)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any E2f6 Mutation: 12 strains or lines available

References

• Original: J:99185 Pohlers M, et al., A role for E2F6 in the restriction of male-germ-cell-specific gene expression. Curr Biol. 2005 Jun 7;15(11):1051-7
• All: 1 reference(s)