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Mafatm1Staka
Targeted Allele Detail
Nomenclature
Symbol: Mafatm1Staka
Name: v-maf musculoaponeurotic fibrosarcoma oncogene family, protein A (avian); targeted mutation 1, Satoru Takahashi
MGI ID: MGI:3581892
Synonyms: MafA-
Gene: Mafa  Location: Chr15:75746843-75747922 bp, - strand  Genetic Position: Chr15, 34.82 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:99126
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Mutation
description
Allele Type:    Targeted (Null/knockout, Reporter)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsAn NLS-lacZ-neo cassette replaced sequences encoding both the transactivation and basic motif-leucine zipper domains. Beta-galactosidase expression was observed in the lens, somites and olfactory bulb, as well as pancreateic islets. (J:99126)
Phenotypes
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View phenotypes for all genotypes (concatenated display).
Disease models
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Expression
In Mice Carrying this Mutation: 11 assay results
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Mafa Mutation:  9 strains or lines available
References
Original:  J:99126 Zhang C, et al., MafA is a key regulator of glucose-stimulated insulin secretion. Mol Cell Biol. 2005 Jun;25(12):4969-76
All:  7 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
09/27/2016
MGI 6.05
The Jackson Laboratory