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Abca5tm1Akya
Targeted Allele Detail
Nomenclature
Symbol: Abca5tm1Akya
Name: ATP-binding cassette, sub-family A (ABC1), member 5; targeted mutation 1, Akihito Yamaguchi
MGI ID: MGI:3581814
Synonyms: Abca5-
Gene: Abca5  Location: Chr11:110269369-110337716 bp, - strand  Genetic Position: Chr11, 73.53 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:99152
Parent Cell Line:  TT2 (ES Cell)
Strain of Origin:  (C57BL/6NCrlj x CBA/JNCrlj)F1
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutation:    Insertion
 
Mutation detailsInsertion of a neo cassette disrupted the region encoding the Walker A motif of NBD2, exon 31 and parts of exons 30 and 32. (J:99152)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 9 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Abca5 Mutation:  4 strains or lines available
References
Original:  J:99152 Kubo Y, et al., ABCA5 resides in lysosomes, and ABCA5 knockout mice develop lysosomal disease-like symptoms. (Correction: v.25(13):5786). Mol Cell Biol. 2005 May;25(10):4138-49
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
03/24/2020
MGI 6.15
The Jackson Laboratory