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Ybx1tm1Ley
Targeted Allele Detail
Nomenclature
Symbol: Ybx1tm1Ley
Name: Y box protein 1; targeted mutation 1, Timothy J Ley
MGI ID: MGI:3581780
Synonyms: YB-1-
Gene: Ybx1  Location: Chr4:119277981-119294604 bp, - strand  Genetic Position: Chr4, 55.34 cM, cytoband D1
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:99099
Parent Cell Line:  RW-4 (ES Cell)
Strain of Origin:  129X1/SvJ
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA PGK-neo cassette replaced a 9.5 kb genomic sequence containing exon 3, which encodes a portion of the CSD, to disrupt the coding frame of the gene. Western blot of mutant MEFs confirmed absence of wild-type protein. (J:99099)
Phenotypes
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View phenotypes for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 1 assay results
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Ybx1 Mutation:  8 strains or lines available
References
Original:  J:99099 Lu ZH, et al., YB-1 is important for late-stage embryonic development, optimal cellular stress responses, and the prevention of premature senescence. Mol Cell Biol. 2005 Jun;25(11):4625-37
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
11/29/2016
MGI 6.06
The Jackson Laboratory