Ybx1^tm1Ley
Targeted Allele Detail

Summary

• Symbol: Ybx1^tm1Ley
• Name: Y box protein 1; targeted mutation 1, Timothy J Ley
• MGI ID: MGI:3581780
• Synonyms: YB-1^-
• Gene: Ybx1 Location: Chr4:119135178-119151801 bp, - strand Genetic Position: Chr4, 55.34 cM, cytoband D1
• Alliance: Ybx1^tm1Ley page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:99099
• Parent Cell Line: RW-4 (ES Cell)
• Strain of Origin: 129X1/SvJ

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A PGK-neo cassette replaced a 9.5 kb genomic sequence containing exon 3, which encodes a portion of the CSD, to disrupt the coding frame of the gene. Western blot of mutant MEFs confirmed absence of wild-type protein. (J:99099)

Expression

In Mice Carrying this Mutation:	6 assay results
In Structures Affected by this Mutation:	6 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ybx1 Mutation: 18 strains or lines available

References

• Original: J:99099 Lu ZH, et al., YB-1 is important for late-stage embryonic development, optimal cellular stress responses, and the prevention of premature senescence. Mol Cell Biol. 2005 Jun;25(11):4625-37
• All: 5 reference(s)