Igh-Jtm1Bds
Targeted Allele Detail
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Symbol: |
Igh-Jtm1Bds |
Name: |
immunoglobulin heavy chain, joining region; targeted mutation 1, B David Stollar |
MGI ID: |
MGI:3581661 |
Synonyms: |
IgMa |
Gene: |
Igh-J Location: unknown Genetic Position: Chr12, Syntenic
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Germline Transmission: |
Earliest citation of germline transmission:
J:71617
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Parent Cell Line: |
J1 (ES Cell)
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Strain of Origin: |
129S4/SvJae
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Allele Type: |
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Targeted (Inserted expressed sequence) |
Mutations: |
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Insertion, Intergenic deletion
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Mutation details: A targeting construct was designed to insert a rearranged H chain of a physiologically selected ssDNA-binding antibody into the locus. The DQ52 and JH elements were deleted upon recombination. Flow cytometry demonstrated that 67% of heterozygous mice expressed only the mutant allele, and up to 31% expressed the endogenous allele exclusively.
(J:71617)
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View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Carrying any Igh-J Mutation: |
13 strains or lines available
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Original: |
J:71617 Li J, et al., The rearranged v(h) domain of a physiologically selected anti-single-stranded dna antibody as a precursor for formation of igm and igg antibodies to diverse antigens. J Immunol. 2001 Oct 1;167(7):3746-55 |
All: |
2 reference(s) |
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