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Igh-Jtm1Bds
Targeted Allele Detail
Nomenclature
Symbol: Igh-Jtm1Bds
Name: immunoglobulin heavy chain, joining region; targeted mutation 1, B David Stollar
MGI ID: MGI:3581661
Synonyms: IgMa
Gene: Igh-J  Location: unknown  Genetic Position: Chr12, Syntenic
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:71617
Parent Cell Line:  J1 (ES Cell)
Strain of Origin:  129S4/SvJae
Mutation
description
Allele Type:    Targeted (Inserted expressed sequence)
Mutations:    Insertion, Intergenic deletion
 
Mutation detailsA targeting construct was designed to insert a rearranged H chain of a physiologically selected ssDNA-binding antibody into the locus. The DQ52 and JH elements were deleted upon recombination. Flow cytometry demonstrated that 67% of heterozygous mice expressed only the mutant allele, and up to 31% expressed the endogenous allele exclusively. (J:71617)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Igh-J Mutation:  14 strains or lines available
References
Original:  J:71617 Li J, et al., The rearranged v(h) domain of a physiologically selected anti-single-stranded dna antibody as a precursor for formation of igm and igg antibodies to diverse antigens. J Immunol. 2001 Oct 1;167(7):3746-55
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
05/10/2022
MGI 6.19
The Jackson Laboratory